Volume 6, Issue 4, December 2020, Page: 77-81
Effects of Aegle marmelos (L.) Methanolic Leaf Extracts on Cardiovascular Parameters in Diabetic Rats
Ravi Babu Birudu, Department of Zoology & Aquaculture, Acharya Nagarjuna University, Andhra Pradesh, India
Padmavathi Pamulapati, Department of Zoology & Aquaculture, Acharya Nagarjuna University, Andhra Pradesh, India
Manoharan Sathish Kumar, Department of Pharmacology, Bapatla College of Pharmacy, Bapatla, Andhra Pradesh, India
Received: Sep. 15, 2020;       Accepted: Sep. 27, 2020;       Published: Oct. 7, 2020
DOI: 10.11648/j.jdmp.20200604.11      View  19      Downloads  21
Abstract
Aegle marmelos (L.) Correa is a widely found plant in India as well as in South Asia. For more than several centuries it is being widely used for its medicinal properties. The objective of the study was to evaluate the cardiovascular changes in alloxan induced diabetic rats treated with methanolic leaf extracts of Aegle marmelos. 5 treatment groups (namely control, diseased, low dose (100mg/kg), medium dose (250mg/kg) and high dose (500mg/kg) of methanolic leaf extracts were used in the study. The cardiovasculareffects were evaluated by the determination of Very-Low-Density Lipoprotein (VLDL), Serum Sialic Acid, Glutathione Peroxidase, Serum Catalase, Ascorbic acid, Sodium, Potassium, and Chloride levels. High dose treatment group showed significant decrease in Very-Low-Density Lipoprotein (VLDL), Serum Sialic Acid, Glutathione Peroxidase, Serum Catalase, Ascorbic acid, Sodium, Potassium, and Chloride levels when compared with the diseased treatment groups. Though Low and medium dose treated animals showed insignificant decrease in these cardiovascular parameters when compared with high dose treatment group as well as diseased group. The effects of high dose treatment on cardiovascular parameters were very significant as that of control group. Through the cardiovascular parameters it is evident that the highdose of methonolic leaf extract of Aegle marmelos can be used the treatment of diabetes and its cardiovascular complications.
Keywords
Aegle marmelos, Rutaceae, Bael, Alloxan, Diabetes, Cardiovascular Parameters
To cite this article
Ravi Babu Birudu, Padmavathi Pamulapati, Manoharan Sathish Kumar, Effects of Aegle marmelos (L.) Methanolic Leaf Extracts on Cardiovascular Parameters in Diabetic Rats, Journal of Diseases and Medicinal Plants. Vol. 6, No. 4, 2020, pp. 77-81. doi: 10.11648/j.jdmp.20200604.11
Copyright
Copyright © 2020 Authors retain the copyright of this article.
This article is an open access article distributed under the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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