Evaluation of the Antidiabetic Properties of Hydro-Alcoholic Extract and Its Fractions from <i>Physalis peruviana</i> L. Leaves on Streptozotocin-Induced Diabetic Wistar Rats

Felicien M. Kasali; Charles Ntungwen Fokunang; Joseph Ngoupayo; Estella Tembe-Fokunang; Bathelemy Ngameni; Borgia Njinkio; Frederick Kechia; Justin N. Kadima; Tsague Marthe; Oyono Victor; Wilfred Mbacham; Bonaventure Tchaleu Ngadjui

doi:doi:10.11648/j.jdmp.20160206.12

Evaluation of the Antidiabetic Properties of Hydro-Alcoholic Extract and Its Fractions from Physalis peruviana L. Leaves on Streptozotocin-Induced Diabetic Wistar Rats

Felicien M. Kasali, Charles Ntungwen Fokunang, Joseph Ngoupayo, Estella Tembe-Fokunang, Bathelemy Ngameni, Borgia Njinkio, Frederick Kechia, Justin N. Kadima, Tsague Marthe, Oyono Victor, Wilfred Mbacham, Bonaventure Tchaleu Ngadjui

Published in Journal of Diseases and Medicinal Plants (Volume 2, Issue 6)

Received: 10 July 2016 Accepted: 20 July 2016 Published: 22 November 2016

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Abstract

The purpose of this study was to investigate the antidiabetic activity of extracts from leaves of Physalis peruviana L. used in the Eastern part of the Democratic Republic of the Congo used against diabetes. Different fractions with hexane, ethyl acetate and residue were obtained from the hydroalcoholic extract of Physalis peruviana leaves. The antidiabetic evaluation of hydroalcoholic and its fractions was evaluated in diabetic rats by a single administration of streptozotocin (50 mg/kg body weight) intravenously. The Reference group received glibenclamide (6.5 mg/kg body weight) and each test group received 100 mg/kg of body weight. Those groups were compared with a control group which received only a Tween 20 solution (1 ml per 100 g body weight). Serum biochemical profiles were evaluated by some blood markers including serum glucose, serum alanine transaminase (ALT), serum aspartate transaminase (AST) serum creatinine, total protein, triglyceride, total cholesterol, HDL-cholesterol and LDL-cholesterol. Antidiabetic profile evaluation showed no significant variation (P < 0.05) in blood glucose between groups after 28 days of treatment. There was no significant difference in the biochemical markers change including creatinine, ALT, AST, total protein, triglycerides, total cholesterol, HDL-cholesterol and LDL-cholesterol. The hydroalcoholic extract from the leaves of Physalis peruviana L. and its fractions showed antidiabetic activity suggesting future detailed studies for new chemical entities lead drug discovery.

Published in	Journal of Diseases and Medicinal Plants (Volume 2, Issue 6)
DOI	10.11648/j.jdmp.20160206.12
Page(s)	67-73
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2024. Published by Science Publishing Group

Keywords

Physalis peruviana, Antidiabetic, Hydroalcoholic Extract, Streptozotocin, Biochemical Parameters, Wistar Rats

References

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APA Style

Felicien M. Kasali, Charles Ntungwen Fokunang, Joseph Ngoupayo, Estella Tembe-Fokunang, Bathelemy Ngameni, et al. (2016). Evaluation of the Antidiabetic Properties of Hydro-Alcoholic Extract and Its Fractions from Physalis peruviana L. Leaves on Streptozotocin-Induced Diabetic Wistar Rats. Journal of Diseases and Medicinal Plants, 2(6), 67-73. https://doi.org/10.11648/j.jdmp.20160206.12

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ACS Style

Felicien M. Kasali; Charles Ntungwen Fokunang; Joseph Ngoupayo; Estella Tembe-Fokunang; Bathelemy Ngameni, et al. Evaluation of the Antidiabetic Properties of Hydro-Alcoholic Extract and Its Fractions from Physalis peruviana L. Leaves on Streptozotocin-Induced Diabetic Wistar Rats. J. Dis. Med. Plants 2016, 2(6), 67-73. doi: 10.11648/j.jdmp.20160206.12

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AMA Style

Felicien M. Kasali, Charles Ntungwen Fokunang, Joseph Ngoupayo, Estella Tembe-Fokunang, Bathelemy Ngameni, et al. Evaluation of the Antidiabetic Properties of Hydro-Alcoholic Extract and Its Fractions from Physalis peruviana L. Leaves on Streptozotocin-Induced Diabetic Wistar Rats. J Dis Med Plants. 2016;2(6):67-73. doi: 10.11648/j.jdmp.20160206.12

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@article{10.11648/j.jdmp.20160206.12,
  author = {Felicien M. Kasali and Charles Ntungwen Fokunang and Joseph Ngoupayo and Estella Tembe-Fokunang and Bathelemy Ngameni and Borgia Njinkio and Frederick Kechia and Justin N. Kadima and Tsague Marthe and Oyono Victor and Wilfred Mbacham and Bonaventure Tchaleu Ngadjui},
  title = {Evaluation of the Antidiabetic Properties of Hydro-Alcoholic Extract and Its Fractions from Physalis peruviana L. Leaves on Streptozotocin-Induced Diabetic Wistar Rats},
  journal = {Journal of Diseases and Medicinal Plants},
  volume = {2},
  number = {6},
  pages = {67-73},
  doi = {10.11648/j.jdmp.20160206.12},
  url = {https://doi.org/10.11648/j.jdmp.20160206.12},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.jdmp.20160206.12},
  abstract = {The purpose of this study was to investigate the antidiabetic activity of extracts from leaves of Physalis peruviana L. used in the Eastern part of the Democratic Republic of the Congo used against diabetes. Different fractions with hexane, ethyl acetate and residue were obtained from the hydroalcoholic extract of Physalis peruviana leaves. The antidiabetic evaluation of hydroalcoholic and its fractions was evaluated in diabetic rats by a single administration of streptozotocin (50 mg/kg body weight) intravenously. The Reference group received glibenclamide (6.5 mg/kg body weight) and each test group received 100 mg/kg of body weight. Those groups were compared with a control group which received only a Tween 20 solution (1 ml per 100 g body weight). Serum biochemical profiles were evaluated by some blood markers including serum glucose, serum alanine transaminase (ALT), serum aspartate transaminase (AST) serum creatinine, total protein, triglyceride, total cholesterol, HDL-cholesterol and LDL-cholesterol. Antidiabetic profile evaluation showed no significant variation (P < 0.05) in blood glucose between groups after 28 days of treatment. There was no significant difference in the biochemical markers change including creatinine, ALT, AST, total protein, triglycerides, total cholesterol, HDL-cholesterol and LDL-cholesterol. The hydroalcoholic extract from the leaves of Physalis peruviana L. and its fractions showed antidiabetic activity suggesting future detailed studies for new chemical entities lead drug discovery.},
 year = {2016}
}

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TY - JOUR
T1 - Evaluation of the Antidiabetic Properties of Hydro-Alcoholic Extract and Its Fractions from Physalis peruviana L. Leaves on Streptozotocin-Induced Diabetic Wistar Rats
AU - Felicien M. Kasali
AU - Charles Ntungwen Fokunang
AU - Joseph Ngoupayo
AU - Estella Tembe-Fokunang
AU - Bathelemy Ngameni
AU - Borgia Njinkio
AU - Frederick Kechia
AU - Justin N. Kadima
AU - Tsague Marthe
AU - Oyono Victor
AU - Wilfred Mbacham
AU - Bonaventure Tchaleu Ngadjui
Y1 - 2016/11/22
PY - 2016
N1 - https://doi.org/10.11648/j.jdmp.20160206.12
DO - 10.11648/j.jdmp.20160206.12
T2 - Journal of Diseases and Medicinal Plants
JF - Journal of Diseases and Medicinal Plants
JO - Journal of Diseases and Medicinal Plants
SP - 67
EP - 73
PB - Science Publishing Group
SN - 2469-8210
UR - https://doi.org/10.11648/j.jdmp.20160206.12
AB - The purpose of this study was to investigate the antidiabetic activity of extracts from leaves of Physalis peruviana L. used in the Eastern part of the Democratic Republic of the Congo used against diabetes. Different fractions with hexane, ethyl acetate and residue were obtained from the hydroalcoholic extract of Physalis peruviana leaves. The antidiabetic evaluation of hydroalcoholic and its fractions was evaluated in diabetic rats by a single administration of streptozotocin (50 mg/kg body weight) intravenously. The Reference group received glibenclamide (6.5 mg/kg body weight) and each test group received 100 mg/kg of body weight. Those groups were compared with a control group which received only a Tween 20 solution (1 ml per 100 g body weight). Serum biochemical profiles were evaluated by some blood markers including serum glucose, serum alanine transaminase (ALT), serum aspartate transaminase (AST) serum creatinine, total protein, triglyceride, total cholesterol, HDL-cholesterol and LDL-cholesterol. Antidiabetic profile evaluation showed no significant variation (P < 0.05) in blood glucose between groups after 28 days of treatment. There was no significant difference in the biochemical markers change including creatinine, ALT, AST, total protein, triglycerides, total cholesterol, HDL-cholesterol and LDL-cholesterol. The hydroalcoholic extract from the leaves of Physalis peruviana L. and its fractions showed antidiabetic activity suggesting future detailed studies for new chemical entities lead drug discovery.
VL - 2
IS - 6
ER -

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Author Information

Felicien M. Kasali

Department of Pharmacy, Faculty of Medicine and Pharmacy, Official University of Bukavu, Bukavu, Bukavu-Democratic Republic of Congo
Charles Ntungwen Fokunang

Department of Pharmaco-Toxicology and pharmacokinetics, Faculty of Medicine and Biomedical Sciences, University of Yaounde I, Yaounde, Cameroon
Joseph Ngoupayo

Department of Pharmacognosy and Pharmaceutical Chemistry, Faculty of Medicine and Biomedical Sciences, University of Yaounde I, Yaounde, Cameroon
Estella Tembe-Fokunang

Department of Pharmaco-Toxicology and pharmacokinetics, Faculty of Medicine and Biomedical Sciences, University of Yaounde I, Yaounde, Cameroon
Bathelemy Ngameni

Department of Pharmacognosy and Pharmaceutical Chemistry, Faculty of Medicine and Biomedical Sciences, University of Yaounde I, Yaounde, Cameroon
Borgia Njinkio

Department of Pharmacognosy and Pharmaceutical Chemistry, Faculty of Medicine and Biomedical Sciences, University of Yaounde I, Yaounde, Cameroon
Frederick Kechia

Department of Bacteriology, Virology, Parasitology and Infctious Diseases, Faculty of Medicines and Biomedical Sciences, University of Yaounde I, Yaounde, Cameroon
Justin N. Kadima

Department of Pharmacology, School of Medicine and Health Sciences, University of Rwanda, Butare, Rwanda
Tsague Marthe

Department of Biomedical Sciences, University of Ngaoundere, Ngaoundere, Cameroon
Oyono Victor

Department of Pharmacognosy and Pharmaceutical Chemistry, Faculty of Medicine and Biomedical Sciences, University of Yaounde I, Yaounde, Cameroon
Wilfred Mbacham

Department of Biochemistry, Faculty of Sciences, University of Yaounde I, Yaounde, Cameroon
Bonaventure Tchaleu Ngadjui

Department of Pharmacognosy and Pharmaceutical Chemistry, Faculty of Medicine and Biomedical Sciences, University of Yaounde I, Yaounde, Cameroon

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APA Style

Felicien M. Kasali, Charles Ntungwen Fokunang, Joseph Ngoupayo, Estella Tembe-Fokunang, Bathelemy Ngameni, et al. (2016). Evaluation of the Antidiabetic Properties of Hydro-Alcoholic Extract and Its Fractions from Physalis peruviana L. Leaves on Streptozotocin-Induced Diabetic Wistar Rats. Journal of Diseases and Medicinal Plants, 2(6), 67-73. https://doi.org/10.11648/j.jdmp.20160206.12

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ACS Style

Felicien M. Kasali; Charles Ntungwen Fokunang; Joseph Ngoupayo; Estella Tembe-Fokunang; Bathelemy Ngameni, et al. Evaluation of the Antidiabetic Properties of Hydro-Alcoholic Extract and Its Fractions from Physalis peruviana L. Leaves on Streptozotocin-Induced Diabetic Wistar Rats. J. Dis. Med. Plants 2016, 2(6), 67-73. doi: 10.11648/j.jdmp.20160206.12

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AMA Style

Felicien M. Kasali, Charles Ntungwen Fokunang, Joseph Ngoupayo, Estella Tembe-Fokunang, Bathelemy Ngameni, et al. Evaluation of the Antidiabetic Properties of Hydro-Alcoholic Extract and Its Fractions from Physalis peruviana L. Leaves on Streptozotocin-Induced Diabetic Wistar Rats. J Dis Med Plants. 2016;2(6):67-73. doi: 10.11648/j.jdmp.20160206.12

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@article{10.11648/j.jdmp.20160206.12,
  author = {Felicien M. Kasali and Charles Ntungwen Fokunang and Joseph Ngoupayo and Estella Tembe-Fokunang and Bathelemy Ngameni and Borgia Njinkio and Frederick Kechia and Justin N. Kadima and Tsague Marthe and Oyono Victor and Wilfred Mbacham and Bonaventure Tchaleu Ngadjui},
  title = {Evaluation of the Antidiabetic Properties of Hydro-Alcoholic Extract and Its Fractions from Physalis peruviana L. Leaves on Streptozotocin-Induced Diabetic Wistar Rats},
  journal = {Journal of Diseases and Medicinal Plants},
  volume = {2},
  number = {6},
  pages = {67-73},
  doi = {10.11648/j.jdmp.20160206.12},
  url = {https://doi.org/10.11648/j.jdmp.20160206.12},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.jdmp.20160206.12},
  abstract = {The purpose of this study was to investigate the antidiabetic activity of extracts from leaves of Physalis peruviana L. used in the Eastern part of the Democratic Republic of the Congo used against diabetes. Different fractions with hexane, ethyl acetate and residue were obtained from the hydroalcoholic extract of Physalis peruviana leaves. The antidiabetic evaluation of hydroalcoholic and its fractions was evaluated in diabetic rats by a single administration of streptozotocin (50 mg/kg body weight) intravenously. The Reference group received glibenclamide (6.5 mg/kg body weight) and each test group received 100 mg/kg of body weight. Those groups were compared with a control group which received only a Tween 20 solution (1 ml per 100 g body weight). Serum biochemical profiles were evaluated by some blood markers including serum glucose, serum alanine transaminase (ALT), serum aspartate transaminase (AST) serum creatinine, total protein, triglyceride, total cholesterol, HDL-cholesterol and LDL-cholesterol. Antidiabetic profile evaluation showed no significant variation (P < 0.05) in blood glucose between groups after 28 days of treatment. There was no significant difference in the biochemical markers change including creatinine, ALT, AST, total protein, triglycerides, total cholesterol, HDL-cholesterol and LDL-cholesterol. The hydroalcoholic extract from the leaves of Physalis peruviana L. and its fractions showed antidiabetic activity suggesting future detailed studies for new chemical entities lead drug discovery.},
 year = {2016}
}

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