Many factors among which life style and oxidative stress are implicated in the incidence of neurodegenerative diseases. One of the ways to prevent neurodegeneration is to supply the body with antioxidant molecules derived from food. The aim of this study is to evaluate the nutritional value and neuroprotective activities of eggplants on cognitive impaired rat model. Powder was made with the white and purple Solanum melongena and the nutritional value of each was determined. Total phenolic and flavonoid content, antioxidant activity by DPPH scavenging and reducing iron tests, were determined from aqueous, ethanolic and hydroethanolic fruit extracts. The powder and the most active extract of Solanum melongena were used to determine neuroprotective activity in rats. Male wistar rats were divided into 7 groups of 6 each. Morris water maze and radial maze tests were performed at the end of the experiment to assess behaviour in rats. After 28 days, the rats were sacrificed and biochemical investigations such as protein content, reduced glutathione, catalase activity, malondiadehyde and acetylcholinesterase activity were evaluated in brain homogenates. The purple Solamun melongena showed the highest ash (6.06%), calcium (10.50 mg/100 g of desiccated foods), phosphorus (25.75 mg/100 g of desiccated foods), potassium (218.00 mg/100 g of desiccated foods) and zinc (0.18 mg/100 g of desiccated foods) content. On the other hand, white Solanum melongena showed the highest fiber (3.61%) and iron (0.36 mg/100 g of desiccated foods) content. The greatest phenolic content (69.90 mg GAE /g) and flavonoid content (31.54 mg CATE / g) was observed with the purple Solanum melongena. It also presented the best scavenging DPPH activity (EC 50 = 41.91 μg/ml). The group Sm400 showed the best memory learning activity with radial maze tests (0.66 n/min), a significant decrease of malondialdehyde (15.26 µmole/g), acetylcholinesterase activity (0.13 nmol/min/mg protein) and an increase of protein content (43.71µmole/g) (P<0.05). The group Sm10% showed the best memory capacity radial maze tests (0.73 n/min), the lowest malondialdehyde level and acetylcholinesterase activity (12.45 µmole/g and 0.11nmol/min/mg protein respectively) (P<0.05). Purple Solanum melongena could be used to protect neuron functions.
Published in | Journal of Diseases and Medicinal Plants (Volume 10, Issue 2) |
DOI | 10.11648/j.jdmp.20241002.11 |
Page(s) | 17-28 |
Creative Commons |
This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited. |
Copyright |
Copyright © The Author(s), 2024. Published by Science Publishing Group |
Nutrients, Phytochemical Compounds, Cognitive Protection, Solanum melongena
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APA Style
Tsafack, H. D., Tchinda, M. M., Kemtsop, M. P., Tueguem, G. J. T., Nouemsi, A. P. K., et al. (2024). Effect of Nutrients and Phytochemical Compounds of Solanum melongena (Eggplants) on Cognitive Protection in Rats. Journal of Diseases and Medicinal Plants, 10(2), 17-28. https://doi.org/10.11648/j.jdmp.20241002.11
ACS Style
Tsafack, H. D.; Tchinda, M. M.; Kemtsop, M. P.; Tueguem, G. J. T.; Nouemsi, A. P. K., et al. Effect of Nutrients and Phytochemical Compounds of Solanum melongena (Eggplants) on Cognitive Protection in Rats. J. Dis. Med. Plants 2024, 10(2), 17-28. doi: 10.11648/j.jdmp.20241002.11
AMA Style
Tsafack HD, Tchinda MM, Kemtsop MP, Tueguem GJT, Nouemsi APK, et al. Effect of Nutrients and Phytochemical Compounds of Solanum melongena (Eggplants) on Cognitive Protection in Rats. J Dis Med Plants. 2024;10(2):17-28. doi: 10.11648/j.jdmp.20241002.11
@article{10.11648/j.jdmp.20241002.11, author = {Hermine Doungue Tsafack and Mariane Matchinda Tchinda and Michel Pegui Kemtsop and Geradin Joel Tagne Tueguem and Anne Pascale Kengne Nouemsi and Hilaire Macaire Womeni}, title = {Effect of Nutrients and Phytochemical Compounds of Solanum melongena (Eggplants) on Cognitive Protection in Rats }, journal = {Journal of Diseases and Medicinal Plants}, volume = {10}, number = {2}, pages = {17-28}, doi = {10.11648/j.jdmp.20241002.11}, url = {https://doi.org/10.11648/j.jdmp.20241002.11}, eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.jdmp.20241002.11}, abstract = {Many factors among which life style and oxidative stress are implicated in the incidence of neurodegenerative diseases. One of the ways to prevent neurodegeneration is to supply the body with antioxidant molecules derived from food. The aim of this study is to evaluate the nutritional value and neuroprotective activities of eggplants on cognitive impaired rat model. Powder was made with the white and purple Solanum melongena and the nutritional value of each was determined. Total phenolic and flavonoid content, antioxidant activity by DPPH scavenging and reducing iron tests, were determined from aqueous, ethanolic and hydroethanolic fruit extracts. The powder and the most active extract of Solanum melongena were used to determine neuroprotective activity in rats. Male wistar rats were divided into 7 groups of 6 each. Morris water maze and radial maze tests were performed at the end of the experiment to assess behaviour in rats. After 28 days, the rats were sacrificed and biochemical investigations such as protein content, reduced glutathione, catalase activity, malondiadehyde and acetylcholinesterase activity were evaluated in brain homogenates. The purple Solamun melongena showed the highest ash (6.06%), calcium (10.50 mg/100 g of desiccated foods), phosphorus (25.75 mg/100 g of desiccated foods), potassium (218.00 mg/100 g of desiccated foods) and zinc (0.18 mg/100 g of desiccated foods) content. On the other hand, white Solanum melongena showed the highest fiber (3.61%) and iron (0.36 mg/100 g of desiccated foods) content. The greatest phenolic content (69.90 mg GAE /g) and flavonoid content (31.54 mg CATE / g) was observed with the purple Solanum melongena. It also presented the best scavenging DPPH activity (EC 50 = 41.91 μg/ml). The group Sm400 showed the best memory learning activity with radial maze tests (0.66 n/min), a significant decrease of malondialdehyde (15.26 µmole/g), acetylcholinesterase activity (0.13 nmol/min/mg protein) and an increase of protein content (43.71µmole/g) (PSolanum melongena could be used to protect neuron functions. }, year = {2024} }
TY - JOUR T1 - Effect of Nutrients and Phytochemical Compounds of Solanum melongena (Eggplants) on Cognitive Protection in Rats AU - Hermine Doungue Tsafack AU - Mariane Matchinda Tchinda AU - Michel Pegui Kemtsop AU - Geradin Joel Tagne Tueguem AU - Anne Pascale Kengne Nouemsi AU - Hilaire Macaire Womeni Y1 - 2024/04/11 PY - 2024 N1 - https://doi.org/10.11648/j.jdmp.20241002.11 DO - 10.11648/j.jdmp.20241002.11 T2 - Journal of Diseases and Medicinal Plants JF - Journal of Diseases and Medicinal Plants JO - Journal of Diseases and Medicinal Plants SP - 17 EP - 28 PB - Science Publishing Group SN - 2469-8210 UR - https://doi.org/10.11648/j.jdmp.20241002.11 AB - Many factors among which life style and oxidative stress are implicated in the incidence of neurodegenerative diseases. One of the ways to prevent neurodegeneration is to supply the body with antioxidant molecules derived from food. The aim of this study is to evaluate the nutritional value and neuroprotective activities of eggplants on cognitive impaired rat model. Powder was made with the white and purple Solanum melongena and the nutritional value of each was determined. Total phenolic and flavonoid content, antioxidant activity by DPPH scavenging and reducing iron tests, were determined from aqueous, ethanolic and hydroethanolic fruit extracts. The powder and the most active extract of Solanum melongena were used to determine neuroprotective activity in rats. Male wistar rats were divided into 7 groups of 6 each. Morris water maze and radial maze tests were performed at the end of the experiment to assess behaviour in rats. After 28 days, the rats were sacrificed and biochemical investigations such as protein content, reduced glutathione, catalase activity, malondiadehyde and acetylcholinesterase activity were evaluated in brain homogenates. The purple Solamun melongena showed the highest ash (6.06%), calcium (10.50 mg/100 g of desiccated foods), phosphorus (25.75 mg/100 g of desiccated foods), potassium (218.00 mg/100 g of desiccated foods) and zinc (0.18 mg/100 g of desiccated foods) content. On the other hand, white Solanum melongena showed the highest fiber (3.61%) and iron (0.36 mg/100 g of desiccated foods) content. The greatest phenolic content (69.90 mg GAE /g) and flavonoid content (31.54 mg CATE / g) was observed with the purple Solanum melongena. It also presented the best scavenging DPPH activity (EC 50 = 41.91 μg/ml). The group Sm400 showed the best memory learning activity with radial maze tests (0.66 n/min), a significant decrease of malondialdehyde (15.26 µmole/g), acetylcholinesterase activity (0.13 nmol/min/mg protein) and an increase of protein content (43.71µmole/g) (PSolanum melongena could be used to protect neuron functions. VL - 10 IS - 2 ER -