Due to some undesirable secondary reaction of synthetic drugs, natural products and plants with medicinal properties are been exploited in controlling and treating many chronic diseases including diabetes. Oxidative stress has a major effects in diabetes and the difficulties associated with it including hepatotoxicity. Newbouldia laevis is a traditional medicinal plant known to possess antimicrobial, anticonvulsant, sedative, analgesic, anti-inflammatory and antidiarrheal properties. However, there is scanty information on its utilization in diabetes management. This investigation was carried out to determine the potentials of aqueous ethanolic extract of Newbouldia laevis leaves to protect hepatic tissues of rats from diabetes caused by oxidative stress and hapatocellular injury. Diabetic condition was effected in rats by single intraperitoneal injection of alloxan. Rats were slaughtered by cervical dislocation after administration of Newbouldia leave extracts at dose of 200 and 400 mg/kg bw for 21 days. Hepatic tissues were analysed for catalase, superoxide dismutase (SOD) and glutathione (GSH) activities, lipid peroxidation, lipid profile and protein content were also evaluated. Alkaline phosphatase (ALP), aspartate aminotransferase (AST) and alanine aminotransferase (ALT) which are hepatic biomarkers were analysed in the blood serum. Significant reduction (p<0.05) of GSH, catalase, and SOD activities were effected by diabetes induction, also rise in hepatic biomarkers and lipid peroxidation was observed. Treatment with extract at 200 mg/kg caused significant (p<0.05) increased activities of the studied antioxidant biomarkers and reduced lipid peroxidation. It also led to a reduced activity of hepatic biomarkers. These results shows antioxidant protective properties of N. laevis leaves against rise in oxidative stress and hepatocellular injury in diabetic rat’s hepatic tissues at lower dose, indicating that the extract may possess antioxidant activities in diabetics.
| Published in | Journal of Diseases and Medicinal Plants (Volume 6, Issue 4) |
| DOI | 10.11648/j.jdmp.20200604.14 |
| Page(s) | 87-91 |
| Creative Commons |
This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited. |
| Copyright |
Copyright © The Author(s), 2024. Published by Science Publishing Group |
Antioxidant, Diabetes, Hepatic Biomarkers, Hepatocellular Injury
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APA Style
Jane Ngozi Okafor, Ochuko Lucky Erukainure, John Adebayo Ajiboye, Michael Obi Etoamaihe, Ijeoma Lynda Eboagwu, et al. (2020). Antioxidant Protective Effect of Newbouldia laevis on Hepatotoxicity in Alloxan-Induced Diabetes in Rats. Journal of Diseases and Medicinal Plants, 6(4), 87-91. https://doi.org/10.11648/j.jdmp.20200604.14
ACS Style
Jane Ngozi Okafor; Ochuko Lucky Erukainure; John Adebayo Ajiboye; Michael Obi Etoamaihe; Ijeoma Lynda Eboagwu, et al. Antioxidant Protective Effect of Newbouldia laevis on Hepatotoxicity in Alloxan-Induced Diabetes in Rats. J. Dis. Med. Plants 2020, 6(4), 87-91. doi: 10.11648/j.jdmp.20200604.14
AMA Style
Jane Ngozi Okafor, Ochuko Lucky Erukainure, John Adebayo Ajiboye, Michael Obi Etoamaihe, Ijeoma Lynda Eboagwu, et al. Antioxidant Protective Effect of Newbouldia laevis on Hepatotoxicity in Alloxan-Induced Diabetes in Rats. J Dis Med Plants. 2020;6(4):87-91. doi: 10.11648/j.jdmp.20200604.14
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Download@article{10.11648/j.jdmp.20200604.14,
author = {Jane Ngozi Okafor and Ochuko Lucky Erukainure and John Adebayo Ajiboye and Michael Obi Etoamaihe and Ijeoma Lynda Eboagwu and Sunday Oluwaseun Adenekan},
title = {Antioxidant Protective Effect of Newbouldia laevis on Hepatotoxicity in Alloxan-Induced Diabetes in Rats},
journal = {Journal of Diseases and Medicinal Plants},
volume = {6},
number = {4},
pages = {87-91},
doi = {10.11648/j.jdmp.20200604.14},
url = {https://doi.org/10.11648/j.jdmp.20200604.14},
eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.jdmp.20200604.14},
abstract = {Due to some undesirable secondary reaction of synthetic drugs, natural products and plants with medicinal properties are been exploited in controlling and treating many chronic diseases including diabetes. Oxidative stress has a major effects in diabetes and the difficulties associated with it including hepatotoxicity. Newbouldia laevis is a traditional medicinal plant known to possess antimicrobial, anticonvulsant, sedative, analgesic, anti-inflammatory and antidiarrheal properties. However, there is scanty information on its utilization in diabetes management. This investigation was carried out to determine the potentials of aqueous ethanolic extract of Newbouldia laevis leaves to protect hepatic tissues of rats from diabetes caused by oxidative stress and hapatocellular injury. Diabetic condition was effected in rats by single intraperitoneal injection of alloxan. Rats were slaughtered by cervical dislocation after administration of Newbouldia leave extracts at dose of 200 and 400 mg/kg bw for 21 days. Hepatic tissues were analysed for catalase, superoxide dismutase (SOD) and glutathione (GSH) activities, lipid peroxidation, lipid profile and protein content were also evaluated. Alkaline phosphatase (ALP), aspartate aminotransferase (AST) and alanine aminotransferase (ALT) which are hepatic biomarkers were analysed in the blood serum. Significant reduction (pN. laevis leaves against rise in oxidative stress and hepatocellular injury in diabetic rat’s hepatic tissues at lower dose, indicating that the extract may possess antioxidant activities in diabetics.},
year = {2020}
}
TY - JOUR T1 - Antioxidant Protective Effect of Newbouldia laevis on Hepatotoxicity in Alloxan-Induced Diabetes in Rats AU - Jane Ngozi Okafor AU - Ochuko Lucky Erukainure AU - John Adebayo Ajiboye AU - Michael Obi Etoamaihe AU - Ijeoma Lynda Eboagwu AU - Sunday Oluwaseun Adenekan Y1 - 2020/12/22 PY - 2020 N1 - https://doi.org/10.11648/j.jdmp.20200604.14 DO - 10.11648/j.jdmp.20200604.14 T2 - Journal of Diseases and Medicinal Plants JF - Journal of Diseases and Medicinal Plants JO - Journal of Diseases and Medicinal Plants SP - 87 EP - 91 PB - Science Publishing Group SN - 2469-8210 UR - https://doi.org/10.11648/j.jdmp.20200604.14 AB - Due to some undesirable secondary reaction of synthetic drugs, natural products and plants with medicinal properties are been exploited in controlling and treating many chronic diseases including diabetes. Oxidative stress has a major effects in diabetes and the difficulties associated with it including hepatotoxicity. Newbouldia laevis is a traditional medicinal plant known to possess antimicrobial, anticonvulsant, sedative, analgesic, anti-inflammatory and antidiarrheal properties. However, there is scanty information on its utilization in diabetes management. This investigation was carried out to determine the potentials of aqueous ethanolic extract of Newbouldia laevis leaves to protect hepatic tissues of rats from diabetes caused by oxidative stress and hapatocellular injury. Diabetic condition was effected in rats by single intraperitoneal injection of alloxan. Rats were slaughtered by cervical dislocation after administration of Newbouldia leave extracts at dose of 200 and 400 mg/kg bw for 21 days. Hepatic tissues were analysed for catalase, superoxide dismutase (SOD) and glutathione (GSH) activities, lipid peroxidation, lipid profile and protein content were also evaluated. Alkaline phosphatase (ALP), aspartate aminotransferase (AST) and alanine aminotransferase (ALT) which are hepatic biomarkers were analysed in the blood serum. Significant reduction (pN. laevis leaves against rise in oxidative stress and hepatocellular injury in diabetic rat’s hepatic tissues at lower dose, indicating that the extract may possess antioxidant activities in diabetics. VL - 6 IS - 4 ER -
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